Abstract
3-Amino-3-phenylpropionamide derivatives were produced as small molecule mimics of the cyclic octapeptide octreotide from readily available imine 1. The compounds exhibit high affinity for the mu opioid receptor.
MeSH terms
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Animals
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Benzylamines / chemical synthesis*
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Benzylamines / pharmacology
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Brain Chemistry
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CHO Cells
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Cricetinae
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Crystallography, X-Ray
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Drug Design
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Humans
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Ligands
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Octreotide / analogs & derivatives
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Octreotide / pharmacology
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Rats
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Receptors, Opioid, mu / drug effects*
Substances
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Benzylamines
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Ligands
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Receptors, Opioid, mu
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3-Tyr-octreotide
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Octreotide